Human Sera
Cayman Chemical FentIconazolenItrate 100mg
An antimicrobial imidazole; active against clinical isolates of Candida species (MICs = 0.12-32 μg/ml); active against clinical isolates of bacteria associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria associated with skin infections (MICs = ≤0.03->16 μg/ml); inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically)
Cayman Chemical Maytnsnol 50mg
An ansa macrolide; inhibits polymerization and induces depolymerization of bovine brain tubulin (EC50s = 12 and 43 µM, respectively); inhibits sea urchin egg mitosis at 10 µM and decreases proliferation of KB nasopharyngeal cancer cells (EC50 = 0.19 UG/ml)
Cayman Chemical XnthosIn 5-monphosphate 50mg
An intermediate in purine metabolism, the product of the rate limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis.
Cayman Chemical 5 NCyclopropylcarboxamIdo 50mg
A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity; stimulates the production of cyclic AMP in CHO-K1 cells with an EC50 value of 5.3 µM
Cayman Chemical IsoquercItrosIde 50mg
A 3-O-glucoside of quercetin that displays antioxidant and chemoprotective effects both in vitro and in vivo.
Cayman Chemical MndIpropamId 50mg
A fungicide; inhibits cellulose synthesis and germ tube elongation in P. infestans at 68 nM; reduces mycelial growth of Phytophthora and P. litchi (EC50s = 0.008-0.03 mg/L); toxic to zebrafish embryos, larvae, and adults (LC50s = 19.91, 4.53, and 4.85 mg/L, respectively); has been used as a chemical inducer of proximity to study protein translocation in vitro and in vivo
Cayman Chemical 5methyl2OMethylcytIdIn 100mg
A modified nucleoside; is found in Huh7 cells infected with Zika virus, HCV, poliovirus, or HIV-1 provirus but not uninfected Huh7 cells; inhibits IL-12 and IL-6 release induced by a TLR9 agonist in mouse spleen cell cultures at 4 UG/ml
Cayman Chemical SecoIsolarIcIrSnl DIglucs 50mg
A lignan with diverse biological activities; scavenges DPPH radicals (IC50 = 78.9 μg/ml) in a cell-free assay; dose-dependently inhibits the growth of SW480 human colon cancer cells; dietary administration reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen; increases insulin and decreases glucose serum levels in rats with streptozotocin-induced diabetes at 20 mg/kg; decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery at a 20 mg/kg per day
Cayman Chemical Brmondn 50mg
An α2-adrenergic receptor agonist (Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells); selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain); topical application lowers intraocular pressure in DBA/2J mice, a glaucoma model, to control levels at 0.1% solution; inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day
Cayman Chemical PnaxatrIol 100mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical IsotretInoIn 50mg
A retinoid; increases the doubling time and transcription of RARβ mRNA in various human oral squamous cell carcinoma cells at 1 μM; inhibits proliferation of primary human sebocytes (IC50 = 10 μM); decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at 0.1 μM; reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice at 2 mg/kg per day; slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration at 40 mg/kg
Cayman Chemical DolutegravIr 50mg
A potent inhibitor of HIV integrase (IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro); inhibits HIV-1 viral replication (EC50 = 0.51 nM) in PMBCs; CC50 values are 189 and 52 µM in unstimulated and stimulated PBMCs; prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to NRTIs, NNRTIs, and protease inhibitors and impairs their ability to infect CIP4 cells
Cayman Chemical Caryophylen oxIde 100mg
A bicyclic sesquiterpene; a metabolite of β-caryophyllene that has been found in C. sativa; does not bind to the cannabinoid (CB) receptor CB2 (Ki = >20 µM); induces calcium currents in HL-60 cells expressing CB2 receptors but also does so in CB2-deficient cells; cytotoxic to HepG2, AGS, HeLa, SNU-1 and SNU-16 cells (IC50s = 3.95, 12.6, 13.55, 16.79, and 27.39 µM, respectively); the volatile component of C. sativa sensed by narcotic detection dogs
Cayman Chemical 2DeoxyadenosIn5OdIphos 50mg
A nucleotide diphosphate; inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase at 0.23 mM; levels are increased in erythrocytes isolated from patients with adenosine deaminase deficiency and SCID
Cayman Chemical NSuccInImIdylSACtylthIoac 50mg
A protein-modifying agent; introduces sulfhydryl groups to proteins; used in conjunction with the protein cross-linking reagent SMCC in the conjugation of proteins with IgG antibodies for use in ELISAs